Redefining drug development with precision therapeutics

Redefining drug development with precision therapeutics

Dysruptx is a Glasgow-based biotechnology company developing Dysruptors, a precision-guided class of peptide therapeutic.

Dysruptx is a Glasgow-based biotechnology company developing Dysruptors, a precision-guided class of peptide therapeutic.

01

Naturally engineered with precision

Naturally engineered with precision

Naturally engineered with precision

Naturally engineered with precision

Protein–protein interactions (PPIs) have evolved over millions of years to achieve highly selective partner recognition, ensuring precise and exclusive interactions within complex biological networks

02

Mapping the PPI interface

Mapping the PPI interface

Mapping the PPI interface

Mapping the PPI interface

Dysruptx harnesses the naturally evolved interface of a target PPI, mapping their uniquely selective binding characteristics

03

Discovering Dysruptors

Discovering Dysruptors

Discovering Dysruptors

Discovering Dysruptors

Applying these insights directly into the drug discovery process enables Dysruptx to develop Dysruptors, a class of macrocyclic peptide engineered to mimic and disrupt disease-driving PPIs with precision

04

De-risking Drug Development

By minimising off-target activity at the earliest stages of development, Dysruptors enable a precision targeted approach to treating human disease, dramatically minimising side-effect risk’

Dysruptors

Dysruptors are engineered from the point of discovery to maximise on-target activity while minimising off-target toxicity; addressing a dominant driver of clinical-stage drug failure

A young person with curly hair smiles at the camera while sitting in front of a laptop against a dark background.

Tunable pharmacokinetics

Broad target compatibility

Modality flexibility

Unparalleled Target Selectivity

Potent & Stable

Macrocyclic Peptide (1-3 kDa, NCE)

Patients

Delivering safer, more effective targeted therapies to patients with high unmet medical needs

Pharmaceutical & biotech partners

Reducing a major driver of clinical-stage failure earlier in development — improving efficiency, timelines, and overall risk.

Dysruptors

Dysruptors are engineered from the point of discovery to maximise on-target activity while minimising off-target toxicity; addressing a dominant driver of clinical-stage drug failure

A young person with curly hair smiles at the camera while sitting in front of a laptop against a dark background.

Tunable pharmacokinetics

Broad target compatibility

Modality flexibility

Unparalleled Target Selectivity

Potent & Stable

Macrocyclic Peptide (1-3 kDa, NCE)

Patients

Delivering safer, more effective targeted therapies to patients with high unmet medical needs

Pharmaceutical & biotech partners

Reducing a major driver of clinical-stage failure earlier in development — improving efficiency, timelines, and overall risk.

Dysruptors

Dysruptors are engineered from the point of discovery to maximise on-target activity while minimising off-target toxicity; addressing a dominant driver of clinical-stage drug failure

A young person with curly hair smiles at the camera while sitting in front of a laptop against a dark background.

Tunable pharmacokinetics

Broad target compatibility

Modality flexibility

Unparalleled Target Selectivity

Potent & Stable

Macrocyclic Peptide (1-3 kDa, NCE)

Patients

Delivering safer, more effective targeted therapies to patients with high unmet medical needs

Pharmaceutical & biotech partners

Reducing a major driver of clinical-stage failure earlier in development — improving efficiency, timelines, and overall risk.